Plasmon-resonant gold nanoparticles with variable morphology as optical labels and drug carriers for cytological research

Olga Bibikova; Alexey Popov; Ilya Skovorodkin; Artur Prilepskyi; Timofey Pylaev; Alexander Bykov; Sergey Staroverov; Vladimir Bogatyrev; Valery Tuchin; Matti Kinnunen; Seppo Vainio; Krizstian Kordas; Nikolai Khlebtsov

doi:10.1117/12.2032547

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18 June 2013 Plasmon-resonant gold nanoparticles with variable morphology as optical labels and drug carriers for cytological research

Olga Bibikova, Alexey Popov, Ilya Skovorodkin, Artur Prilepskyi, Timofey Pylaev, Alexander Bykov, Sergey Staroverov, Vladimir Bogatyrev, Valery Tuchin, Matti Kinnunen, Seppo Vainio, Krizstian Kordas, Nikolai Khlebtsov

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Proceedings Volume 8801, Novel Biophotonic Techniques and Applications II; 880102 (2013) https://doi.org/10.1117/12.2032547
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany

Abstract

In this work, two types of nanocomposites, silica-coated nano-sea-urchins and silica-coated gold nanostars, were fabricated. CTAB-coated nano-sea-urchins with an average size of about 100 nm demonstrate an absorption peak near 600-700 nm and stability in aqueous suspension. CTAB was exchanged with m-PEG-SH by an intermediate PEG layer. A layer of silica was synthesized on the nano-sea-urchins surface with thickness of about 20 nm. Nanostars with an average size of about 60 nm with a number of thin sharp branches were fabricated and functionalized by PVP to improve their stability. PVP-coated nanostars were used in optical coherence tomography experiments to show their contrasting properties. After silica-coating, stable and monodispersed nanoparticles with silica shell thickness about 60 nm were obtained. Nontoxicity of the silica-coated nanostars at least until the concentration of nanoparticles about 400 μg/mL was showed by fluorescent cell viability assay using propidium iodide. Extinction coefficient of the gold nanostars and nanocomposites was estimated by a spectrophotometer system in collimated transmission regime.

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Olga Bibikova, Alexey Popov, Ilya Skovorodkin, Artur Prilepskyi, Timofey Pylaev, Alexander Bykov, Sergey Staroverov, Vladimir Bogatyrev, Valery Tuchin, Matti Kinnunen, Seppo Vainio, Krizstian Kordas, and Nikolai Khlebtsov "Plasmon-resonant gold nanoparticles with variable morphology as optical labels and drug carriers for cytological research", Proc. SPIE 8801, Novel Biophotonic Techniques and Applications II, 880102 (18 June 2013); https://doi.org/10.1117/12.2032547

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