Cardiovascular damage after cw and Q-switched 2μm laser irradiation

Ingo Rohde; Jennifer-M. Masch; Dirk Theisen-Kunde; Martin Marczynski-Bühlow; Georg Lutter; Ralf Brinkmann

doi:10.1117/12.2033550

24 June 2013 Cardiovascular damage after cw and Q-switched 2μm laser irradiation

Ingo Rohde, Jennifer-M. Masch, Dirk Theisen-Kunde, Martin Marczynski-Bühlow, Georg Lutter, Ralf Brinkmann

Author Affiliations +

Proceedings Volume 8803, Medical Laser Applications and Laser-Tissue Interactions VI; 88030I (2013) https://doi.org/10.1117/12.2033550
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany

Abstract

Aiming for laser-assisted resection of calcified aortic valve structures for Transcatheter Aortic Valve Implantation (TAVI), a Q-switched Tm:YAG laser emitting at a wavelength of 2.01 μm was used to evaluate the cutting efficiency on highly calcified human aortic leaflets in-vitro. The calcified aortic leaflets were examined regarding ablation rates and debris generation, using a pulse energy of 4.3 mJ, a pulse duration of 0.8-1 μs and a repetition rate of 1 kHz. The radiation was transmitted via a 200 μm core diameter quartz fiber. Resection was performed in a fiber-tissue contact mode on water-covered samples in a dish. The remnant particles were analyzed with respect to quantity and size by light microscopy. Additionally, soft tissue of porcine aortic vessels was examined for histologically detectable thermo-mechanical damage after continuous wave and Q-switched 2μm laser irradiation. An ablation rate of 36.7 ± 25.3 mg/min could be realised on highly calcified aortic leaflets, with 85.4% of the remnant particles being <6 μm in diameter. The maximum damaged area of the soft tissue was < 1 mm for both, cw and pulsed laser irradiation. This limits the expected collateral damage of healthy tissue during the medical procedure. Overall, the Q-switched Tm:YAG laser system showed promising results in cutting calcified aortic valves, transmitting sufficient energy through a small flexible fibre.

Citation Download Citation

Ingo Rohde, Jennifer-M. Masch, Dirk Theisen-Kunde, Martin Marczynski-Bühlow, Georg Lutter, and Ralf Brinkmann "Cardiovascular damage after cw and Q-switched 2μm laser irradiation", Proc. SPIE 8803, Medical Laser Applications and Laser-Tissue Interactions VI, 88030I (24 June 2013); https://doi.org/10.1117/12.2033550

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