24 June 2013 In vivo two-photon imaging of climbing fibers plasticity after laser axotomy
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Abstract
In the adult nervous system, different neuronal classes show different regenerative behavior. Although previous studies demonstrated that olivocerebellar fibers are capable of axonal regeneration in a suitable environment as a response to injury, we have hitherto no details about the real dynamics of fiber regeneration. We set up a model of singularly axotomized climbing fibers (CF) to investigate their reparative properties in the adult central nervous system (CNS) in vivo. Here we describe the approach followed to characterize the reactive plasticity after injury.
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A. L. Allegra Mascaro, P. Cesare, L. Sacconi, G. Grasselli, G. Mandolesi, B. Maco, G. W. Knott, V. De Paola, P. Strata, F. S. Pavone, "In vivo two-photon imaging of climbing fibers plasticity after laser axotomy", Proc. SPIE 8804, Neurophotonics, 880407 (24 June 2013); doi: 10.1117/12.2032180; https://doi.org/10.1117/12.2032180
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