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12 September 2013 Optical tweezing at extremes
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Diamond anvil cells can be used to study the behavior of materials at high pressure by compressing small samples up to hundreds of GigaPascals. There is no mechanical access to the sample once the cell is pressurized but it is possible to observe the sample through the diamond windows. Optical tweezers can be used to measure the mechanical properties of fluids, such as viscosity, by trapping and monitoring micron sized spheres suspended in the fluid. We use a diamond anvil cell within a modified optical tweezers instrument to measure the viscosity of water as a function of pressure up to 1:3GPa. Development of this technique will allow investigations of the mechanical changes in biological cells and other soft materials placed under high pressure.
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Graham M. Gibson, Richard W. Bowman, Filippo Saglimbeni, Roberto Di Leonardo, and Miles J. Padgett "Optical tweezing at extremes", Proc. SPIE 8810, Optical Trapping and Optical Micromanipulation X, 881009 (12 September 2013);

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