Nano-engineered titanium for enhanced bone therapy

Karan Gulati; Gerald J. Atkins; David M. Findlay; Dusan Losic

doi:10.1117/12.2027151

11 September 2013 Nano-engineered titanium for enhanced bone therapy

Karan Gulati, Gerald J. Atkins, David M. Findlay, Dusan Losic

Proceedings Volume 8812, Biosensing and Nanomedicine VI; 88120C (2013) https://doi.org/10.1117/12.2027151
Event: SPIE NanoScience + Engineering, 2013, San Diego, California, United States

Abstract

Current treatment of a number of orthopaedic conditions, for example fractures, bone infection, joint replacement and bone cancers, could be improved if mechanical support could be combined with drug delivery. A very challenging example is that of infection following joint replacement, which is very difficult to treat, can require multiple surgeries and compromises both the implant and the patient’s wellbeing. An implant capable of providing appropriate biomechanics and releasing drugs/proteins locally might ensure improved healing of the traumatized bone. We propose fabrication of nanoengineered titanium bone implants using bioinert titanium wires in order to achieve this goal. Titanium in the form of flat foils and wires were modified by fabrication of titania nanotubes (TNTs), which are hollow self-ordered cylindrical tubes capable of accommodating substantial drug amounts and releasing them locally. To further control the release of drug to over a period of months, a thin layer of biodegradable polymer PLGA poly(lactic-coglycolic acid) was coated onto the drug loaded TNTs. This delayed release of drug and additionally the polymer enhanced bone cell adhesion and proliferation.

Citation Download Citation

Karan Gulati, Gerald J. Atkins, David M. Findlay, and Dusan Losic "Nano-engineered titanium for enhanced bone therapy", Proc. SPIE 8812, Biosensing and Nanomedicine VI, 88120C (11 September 2013); https://doi.org/10.1117/12.2027151

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available