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11 September 2013Nano-engineered titanium for enhanced bone therapy
Current treatment of a number of orthopaedic conditions, for example fractures, bone infection, joint replacement and
bone cancers, could be improved if mechanical support could be combined with drug delivery. A very challenging
example is that of infection following joint replacement, which is very difficult to treat, can require multiple surgeries
and compromises both the implant and the patient’s wellbeing. An implant capable of providing appropriate biomechanics
and releasing drugs/proteins locally might ensure improved healing of the traumatized bone. We propose
fabrication of nanoengineered titanium bone implants using bioinert titanium wires in order to achieve this goal.
Titanium in the form of flat foils and wires were modified by fabrication of titania nanotubes (TNTs), which are hollow
self-ordered cylindrical tubes capable of accommodating substantial drug amounts and releasing them locally. To further control the release of drug to over a period of months, a thin layer of biodegradable polymer PLGA poly(lactic-coglycolic acid) was coated onto the drug loaded TNTs. This delayed release of drug and additionally the polymer
enhanced bone cell adhesion and proliferation.
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Karan Gulati, Gerald J. Atkins, David M. Findlay, Dusan Losic, "Nano-engineered titanium for enhanced bone therapy," Proc. SPIE 8812, Biosensing and Nanomedicine VI, 88120C (11 September 2013); https://doi.org/10.1117/12.2027151