8 October 2013 Spectral investigations on binding of DNA-CTMA complex with tetrameric copper phthalocyanines
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Abstract
The binding of DNA-CTMA (Deoxyribonucleic acid-cetyltrimethylammonium) complex with two tetrameric Copper Phthalocyanine (CuPc) systems, substituted with carboxylic acid (CuPc-COOH) and derivatized further as an imidazolium salt (CuPc-COOR), was investigated in dimethylsulfoxide (DMSO) solutions using UV/Visible Spectroscopy. Absorbance changes at 685 nm (Q band of the CuPc) were monitored as a function of DNA-CTMA added to the dye solution and stock concentrations of DNA-CTMA in DMSO were varied to facilitate observation of the full binding process. Our findings indicated that while binding with DNA-CTMA was more well-defined in the case of CuPc-COOH, the binding profile of the CuPc-COOR showed initial growth followed by decay in its Q-band absorbance which was indicative of a more complex binding mechanism involving the dye and DNA-CTMA. Preliminary findings from photophysical studies involving the CuPc tetramers and DNA-CTMA are also discussed in this paper.
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Narayanan Venkat, Narayanan Venkat, Joy E. Haley, Joy E. Haley, Rachel Swiger, Rachel Swiger, Lei Zhu, Lei Zhu, Xiaoliang Wei, Xiaoliang Wei, Fahima Ouchen, Fahima Ouchen, James G. Grote, James G. Grote, } "Spectral investigations on binding of DNA-CTMA complex with tetrameric copper phthalocyanines", Proc. SPIE 8817, Nanobiosystems: Processing, Characterization, and Applications VI, 88170E (8 October 2013); doi: 10.1117/12.2027207; https://doi.org/10.1117/12.2027207
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