1 October 2013 Protein 'smart' micro/nano-biooptics via femtosecond laser direct writing
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Protein-hydrogel-based free-form three-dimensional (3D) micro/nano-elements with ‘‘smart’’ stimuli-responsiveness fabricated via femtosecond laser direct writing (FsLDW) have attracted increasing efforts for their wide utilities in many fields, such as bio-micro/nano-machine [1], biophotonics [2, 3], etc. All processes of this protein-FsLDW are carried out in proteins’ aqueous solutions, as a result of which the approach is noncontact, maskless and biocompatible. So, we applied the promising FsLDW approach, which, in the construction of protein-based 3D optical microdevices, for example, microlenses. In order to meet the requirements of optical applications, FsLDW system and processing parameters were carefully optimized to achieve high-quality surface and 3D morphology. The photo-crosslinked protein microhydrogels showed a rapid and reversible swell-to-shrink behavior once stimulated by chemical signals, by which the protein microdevices can be dynamically tuned. Because of using protein molecules as “building blocks”, protein-based microelements were demonstrated of good biocompatibility. Based on the valuable and unique merits, protein-based optical micro/nano-elements have great potential for micro/nano-bio-optics, bionics, and novel biomedical applications, etc.
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Yun-Lu Sun, Yun-Lu Sun, Wen-Fei Dong, Wen-Fei Dong, Hong-Bo Sun, Hong-Bo Sun, "Protein 'smart' micro/nano-biooptics via femtosecond laser direct writing", Proc. SPIE 8817, Nanobiosystems: Processing, Characterization, and Applications VI, 88170R (1 October 2013); doi: 10.1117/12.2021484; https://doi.org/10.1117/12.2021484

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