19 September 2013 Ultrasensitive biomolecular assays with amplifying nanowire FET biosensors
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In this paper, we review our recent development and validation of the ultrasensitive electronic biomolecular assays enabled by our novel amplifying nanowire field-effect transistor (nwFET) biosensors. Our semiconductor nwFET biosensor platform technology performs extreme proximity signal amplification in the electrical domain that requires neither labeling nor enzymes nor optics. We have designed and fabricated the biomolecular assay prototypes and developed the corresponding analytical procedures. We have also confirmed their analytical performance in quantitating key protein biomarker in human serum, demonstrating an ultralow limit of detection and concurrently high output current level for the first time.
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Chi On Chui, Chi On Chui, Kyeong-Sik Shin, Kyeong-Sik Shin, Yufei Mao, Yufei Mao, } "Ultrasensitive biomolecular assays with amplifying nanowire FET biosensors", Proc. SPIE 8820, Nanoepitaxy: Materials and Devices V, 88200S (19 September 2013); doi: 10.1117/12.2026914; https://doi.org/10.1117/12.2026914


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