Fractal evaluation of drug amorphicity from optical and scanning electron microscope images

Bogdan-Mihai G. Gavriloaia; Radu C. Vizireanu; Catalin I. Neamtu; Gheorghe V. Gavriloaia

doi:10.1117/12.2022541

26 September 2013 Fractal evaluation of drug amorphicity from optical and scanning electron microscope images

Bogdan-Mihai G. Gavriloaia, Radu C. Vizireanu, Catalin I. Neamtu, Gheorghe V. Gavriloaia

Proceedings Volume 8856, Applications of Digital Image Processing XXXVI; 88561V (2013) https://doi.org/10.1117/12.2022541
Event: SPIE Optical Engineering + Applications, 2013, San Diego, California, United States

Abstract

Amorphous materials are metastable, more reactive than the crystalline ones, and have to be evaluated before pharmaceutical compound formulation. Amorphicity is interpreted as a spatial chaos, and patterns of molecular aggregates of dexamethasone, D, were investigated in this paper by using fractal dimension, FD. Images having three magnifications of D were taken from an optical microscope, OM, and with eight magnifications, from a scanning electron microscope, SEM, were analyzed. The average FD for pattern irregularities of OM images was 1.538, and about 1.692 for SEM images. The FDs of the two kinds of images are less sensitive of threshold level. 3D images were shown to illustrate dependence of FD of threshold and magnification level. As a result, optical image of single scale is enough to characterize the drug amorphicity. As a result, the OM image at a single scale is enough to characterize the amorphicity of D.

Citation Download Citation

Bogdan-Mihai G. Gavriloaia, Radu C. Vizireanu, Catalin I. Neamtu, and Gheorghe V. Gavriloaia "Fractal evaluation of drug amorphicity from optical and scanning electron microscope images", Proc. SPIE 8856, Applications of Digital Image Processing XXXVI, 88561V (26 September 2013); https://doi.org/10.1117/12.2022541

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KEYWORDS

Fractal analysis

Scanning electron microscopy

Electron microscopes

Image resolution

3D image processing

Image processing

Spatial resolution

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