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20 May 2013 Strong hyper-Rayleigh scattering from silver nanoparticle aggregates to be used for the optical bio-sensing assay
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Proceedings Volume 8879, Nano-Bio Sensing, Imaging, and Spectroscopy; 887905 (2013) https://doi.org/10.1117/12.2018703
Event: Nano-Bio Sensing, Imaging and Spectroscopy, 2013, Jeju, Korea, Republic of
Abstract
Hyper-Rayleigh Scattering (HRS) is a second-order nonlinear optical process in which the scattered light can be detected at the second harmonic wavelength of the input laser beam. Due to its incoherent nature, it can be observed from metal nanoparticles whose size is much smaller than the wavelength. Its sensitive response to the nanoparticle aggregation can be used as a powerful diagnostic tool for the detection of biological target molecules. Many previous bio-sensing applications of HRS have used gold nanoparticles as their sensing platform due to easy synthesis and functionalization of them. Here, we demonstrate that the aggregation of silver nanoparticles induced by poly-L-lysine molecules can generate much higher HRS than that from gold nanoparticle aggregates when using a Ti:Sapphire femtosecond laser. In spite of several drawbacks of silver nanoparticle system regarding the nonlinear response to target concentration and the difficulty of surface functionalization compared to the gold nanoparticle system, much higher HRS from silver nanoparticles can be definitely useful for the sensitive detection of very small amount of target molecules.
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Joon Heon Kim, Jung Su Park, and Min-Gon Kim "Strong hyper-Rayleigh scattering from silver nanoparticle aggregates to be used for the optical bio-sensing assay", Proc. SPIE 8879, Nano-Bio Sensing, Imaging, and Spectroscopy, 887905 (20 May 2013); https://doi.org/10.1117/12.2018703
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