Quantitative Muscle Biopsy Analysis

Kenneth R. Castleman; Joseph P. Van Der Meulen; T. L. Munsatt; Howard J. Frieden; Joan Higgins

doi:10.1117/12.955041

20 January 1977 Quantitative Muscle Biopsy Analysis

Kenneth R. Castleman, Joseph P. Van Der Meulen, T. L. Munsatt, Howard J. Frieden, Joan Higgins

Proceedings Volume 0089, Applications of Optics in Medicine and Biology; (1977) https://doi.org/10.1117/12.955041
Event: 20th Annual Technical Symposium, 1976, San Diego, United States

Abstract

Muscle biopsy is an important tool in the diagnosis and study of neuromuscular disease. Modern histo-chemical techniques produce specimens in which the "fast" and "slow" fibers appear visibly different in color. Certain neuromuscular diseases cause the sizes and relative numbers of each fiber type to change. Neurologists use these changes to diagnose the type and severity of disease. This analysis can be either subjective, and hence of limited accuracy, or quantitative and painstakingly tedious. Working in collaboration with the University of Southern California Neurology Department, the Jet Propulsion Laboratory is developing a compact computer system to perform quantitative muscle biopsy analysis quickly and accurately. The system feeds the microscope image into the computer which then isolates and counts the fibers and measures their size. It then prints out graphs showing the size distribution for each type fiber. This information will assist physicians in diagnosing and treating muscle disease and will facilitate research aimed at understanding human muscle disease processes.

Citation Download Citation

Kenneth R. Castleman, Joseph P. Van Der Meulen, T. L. Munsatt, Howard J. Frieden, and Joan Higgins "Quantitative Muscle Biopsy Analysis", Proc. SPIE 0089, Applications of Optics in Medicine and Biology, (20 January 1977); https://doi.org/10.1117/12.955041

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available