Exploration of noninvasive determination of blood glucose concentration by using photoacoustic technique

Zhong Ren; Guodong Liu; Ying Liu; Zhen Huang

doi:10.1117/12.2033271

19 September 2013 Exploration of noninvasive determination of blood glucose concentration by using photoacoustic technique

Zhong Ren, Guodong Liu, Ying Liu, Zhen Huang

Author Affiliations +

Proceedings Volume 8905, International Symposium on Photoelectronic Detection and Imaging 2013: Laser Sensing and Imaging and Applications; 890510 (2013) https://doi.org/10.1117/12.2033271
Event: ISPDI 2013 - Fifth International Symposium on Photoelectronic Detection and Imaging, 2013, Beijing, China

Abstract

Photoacoustic (PA) noninvasive detection has become a research hotspot of measuring blood glucose concentration (BGC) in recent years. This novel method overcomes greatly the scattering light interference problem must be faced in near infrared (NIR) spectroscopy. A PA based BGC measurement set-up was established, in which a Q switched Nd: YAG pumped optical parametric oscillator (OPO) pulsed laser is used as the excitation source and lateral detection model was used to detetct the PA signals of glucose. To validate the profile model of real time PA signal, determine the characteristic wavelengths of glucose, a series of vitro experiments of glucose aqueous solutions were perfromed. Several wavelengths were preliminarily determined as the characteristic wavelengths via the peak-to-peak values difference. The prediction concentration model was established via least square fitting algorithm between PA peak-to-peak values with their different concentrations. The experimental results demonstrated that the PA profile of glucose is consistent with PA meachnism and the root-mean-squre error (RMSE) of prediction concentration can reach 0.77mmol/L. Therefore, this PA based set-up and scheme has the potential value in the BGC monitoring research.

Citation Download Citation

Zhong Ren, Guodong Liu, Ying Liu, and Zhen Huang "Exploration of noninvasive determination of blood glucose concentration by using photoacoustic technique", Proc. SPIE 8905, International Symposium on Photoelectronic Detection and Imaging 2013: Laser Sensing and Imaging and Applications, 890510 (19 September 2013); https://doi.org/10.1117/12.2033271

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