23 August 2013 Characteristics of chiral and racemic ketoprofen drugs using terahertz time-domain spectroscopy
Author Affiliations +
Proceedings Volume 8909, International Symposium on Photoelectronic Detection and Imaging 2013: Terahertz Technologies and Applications; 89090M (2013) https://doi.org/10.1117/12.2033147
Event: ISPDI 2013 - Fifth International Symposium on Photoelectronic Detection and Imaging, 2013, Beijing, China
Abstract
Absorption spectra of chiral S-(+)- and racemic RS-ketoprofen pharmaceutical molecules in crystalline form were recorded in the terahertz region between 6 and 66 cm-1 (0.2 ~ 2.0 THz) by using time-domain terahertz spectroscopic (THz-TDS) measurement. Different distinctive absorption features were observed which are strikingly sensitive to the change of subtle conformational structures within such isostructural crystal molecules. The results suggest that the THz-TDS technique can be definitely used for distinguishing between chiral and racemic compounds in pharmaceutical and biological fields.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yong Du, Jianjun Liu, and Zhi Hong "Characteristics of chiral and racemic ketoprofen drugs using terahertz time-domain spectroscopy", Proc. SPIE 8909, International Symposium on Photoelectronic Detection and Imaging 2013: Terahertz Technologies and Applications, 89090M (23 August 2013); doi: 10.1117/12.2033147; https://doi.org/10.1117/12.2033147
PROCEEDINGS
6 PAGES


SHARE
Advertisement
Advertisement
Back to Top