30 August 2013 A hp adaptive finite element algorithm for fluorescence molecular tomography based on SPN model
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Proceedings Volume 8910, International Symposium on Photoelectronic Detection and Imaging 2013: Imaging Spectrometer Technologies and Applications; 891018 (2013) https://doi.org/10.1117/12.2033900
Event: ISPDI 2013 - Fifth International Symposium on Photoelectronic Detection and Imaging, 2013, Beijing, China
Abstract
The diffusion approximation of the radiative transport equation is the most widely used model in current researches on fluorescence molecular tomography (FMT), which is limited in some low or zero scattering regions. Recently, the simplified spherical harmonics equations (SPN) model has attracted much attention in modeling the light propagation in small tissue geometries at visible and near-infrared wavelengths. In this paper, we report an efficient numerical method for FMT that combines the advantage of SPN model and hp-FEM. For comparison purposes, hp-FEM and h-FEM are respectively applied in the reconstruction process with diffusion model and SPN model. Simulation experiments on a 3D digital mouse atlas are designed to evaluate the reconstruction methods in terms of the location and the reconstructed fluorescent yield. The experimental results demonstrate that hp-FEM with SPN model, yield more accurate results than h-FEM with DA model does. And the reconstructed results show the potential and feasibility of the proposed approach.
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Hongbo Guo, Hongbo Guo, Yuqing Hou, Yuqing Hou, Xiaowei He, Xiaowei He, Jingjing Yu, Jingjing Yu, Jingxing Cheng, Jingxing Cheng, Xin Pu, Xin Pu, "A hp adaptive finite element algorithm for fluorescence molecular tomography based on SPN model", Proc. SPIE 8910, International Symposium on Photoelectronic Detection and Imaging 2013: Imaging Spectrometer Technologies and Applications, 891018 (30 August 2013); doi: 10.1117/12.2033900; https://doi.org/10.1117/12.2033900
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