The basic study on application of optical coherence tomography to monitoring of viability in vivo rat brain

Manabu Sato; Ippei Nonaka; Tetushi Kitano; Toshihiro Takahashi; Izumi Nishidate

doi:10.1117/12.2034235

29 August 2013 The basic study on application of optical coherence tomography to monitoring of viability in vivo rat brain

Manabu Sato, Ippei Nonaka, Tetushi Kitano, Toshihiro Takahashi, Izumi Nishidate

Author Affiliations +

Proceedings Volume 8914, International Symposium on Photoelectronic Detection and Imaging 2013: Fiber Optic Sensors and Optical Coherence Tomography; 89140S (2013) https://doi.org/10.1117/12.2034235
Event: ISPDI 2013 - Fifth International Symposium on Photoelectronic Detection and Imaging, 2013, Beijing, China

Abstract

The relations and correlation coefficients (CCs) between the OCT signal and the modified state entropy (MSE) of electroencephalogram (EEG) have been studied. Three dimensional (3D) OCT images of rat brains through the thinned skull and EEG have been measured simultaneously anesthetizing to reduce brain activity with the quadrature fringe widefield OCT. Measured 3D volumes are 4mm × 4mm × 2.8mm (Depth). MSE is the product of state entropy of EEG and its effective value. Depth profiles were obtained at the selected three points on the surface of thinned skull. For chosen each depth, the relative signal intensity (RSI) is defined as the ratios of signal intensity to first signal intensity. Deepening the anesthesia RSI increased and MSE decreased to show negative correlation and CCs from -0.31 to -0.56. These results indicate enhancements of the feasibility of OCT as a tool for monitoring/diagnosing the brain tissue viability.

Citation Download Citation

Manabu Sato, Ippei Nonaka, Tetushi Kitano, Toshihiro Takahashi, and Izumi Nishidate "The basic study on application of optical coherence tomography to monitoring of viability in vivo rat brain", Proc. SPIE 8914, International Symposium on Photoelectronic Detection and Imaging 2013: Fiber Optic Sensors and Optical Coherence Tomography, 89140S (29 August 2013); https://doi.org/10.1117/12.2034235

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available