14 January 2014 Imaging of oral pathological tissue using optical coherence tomography
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Abstract
Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival. Interaction of light with tissues may highlight changes in tissue structure and metabolism. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method, being a new high-resolution optical technique that permits tri-dimensional (3-D), real-time imaging of near surface abnormalities in complex tissues. In this study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT investigation. Histopathology validated the results. Areas of OSCC of the buccal mucosa were identified in the OCT images. The elements obserced included extensive epithelial down-growth, the disruption of the basement membrane, with areas of erosion, an epithelial layer that was highly variable in thickness and invasion into the sub-epithelial layers. Therefore, OCT appears to be a highly promising imaging modality.
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Silvana Canjau, Carmen Todea, Cosmin Sinescu, Virgil-Florin Duma, Florin I. Topala, Adrian Gh. Podoleanu, "Imaging of oral pathological tissue using optical coherence tomography", Proc. SPIE 8925, Fifth International Conference on Lasers in Medicine: Biotechnologies Integrated in Daily Medicine, 89250X (14 January 2014); doi: 10.1117/12.2041752; https://doi.org/10.1117/12.2041752
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