4 March 2014 Irradiation with EMOLED improves the healing process in superficial skin wounds
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Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 892604 (2014) https://doi.org/10.1117/12.2037014
Event: SPIE BiOS, 2014, San Francisco, California, United States
Abstract
A faster healing process was observed in superficial skin wounds after irradiation with the EMOLED photocoagulator. The instrument consists of a compact handheld photocoagulation device, useful for inducing coagulation in superficial abrasions. The illumination is provided by a high power blue LED. Blue light is selectively absorbed by haemoglobin and converted into heat through a photothermal effect. In this study, 10 Sprague Dawley rats were mechanically abraded in four regions of their back: two regions were used as a control and the other two were treated with EMOLED. The photothermal effect was monitored by an infrared thermocamera in order to avoid accidental thermal damage. Visual observations, histopathological analysis and non-linear microscopic imaging performed after 8 days from the treatment showed no adverse reactions and no thermal damage in both treated areas and surrounding tissues. Moreover, a faster healing process and a better-recovered morphology was evidenced in the treated tissue with respect to the untreated tissue. Compared to the control regions, a reduced inflammatory response, a higher collagen content, and a skin morphology more similar to normal skin were observed in the treated regions. Collagen organization in the two regions was characterized using image pattern analysis algorithms on SHG images, demonstrating a fully recovered aspect of dermis as well as a faster neocollagenesis in the treated regions. This study demonstrates that the selective photothermal effect we used for inducing immediate coagulation in superficial wounds is associated to a minimal inflammatory response, which provides reduced recovery times and improved healing process.
© (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Riccardo Cicchi, Riccardo Cicchi, Francesca Rossi, Francesca Rossi, Francesca Tatini, Francesca Tatini, Stefano Bacci, Stefano Bacci, Gaetano De Siena, Gaetano De Siena, Domenico Alfieri, Domenico Alfieri, Roberto Pini, Roberto Pini, Francesco S. Pavone, Francesco S. Pavone, } "Irradiation with EMOLED improves the healing process in superficial skin wounds", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 892604 (4 March 2014); doi: 10.1117/12.2037014; https://doi.org/10.1117/12.2037014
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