4 March 2014 Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma
Author Affiliations +
Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89262D (2014) https://doi.org/10.1117/12.2038277
Event: SPIE BiOS, 2014, San Francisco, California, United States
Chemoradiation-resistant cancer cells and unresectable micro-tumors limit treatment efficacy and lead to high nonspecific toxicity or recurrence in head and neck cancers. We show the cancer cell-specific, on-demand enhancement of the chemo- and chemoradiation therapy with mechanical intracellular impact of plasmonic nanobubbles, a laser pulseinduced explosive nano-event, not a particle. We report cellular mechanisms of cancer cell-specific detection and enhancement of the entry drug and X-ray dose and validate these mechanisms in vitro and in vivo for head and neck squamous cell carcinoma. Plasmonic nanobubble technology showed more than 10-fold enhancement of the therapeutic efficacy compared to standard chemoradiation in murine models of primary, microscopic residual and recurrent diseases. At the same time our technology efficiently spared adjacent normal tissues due to the reduction of the effective therapeutic doses of drug by 30-40 fold, X-rays by 15-fold and the treatment time to a single procedure. The developed plasmonic nanobubble technology transforms a standard macro-therapy into a cell-level on-demand theranostic treatment for primary, adjuvant and adjunct applications.
© (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ekaterina Y. Lukianova-Hleb, Ekaterina Y. Lukianova-Hleb, Xiaoyang Ren, Xiaoyang Ren, Rupa R. Sawant, Rupa R. Sawant, Ann M. Gillenwater, Ann M. Gillenwater, Michael Kupferman, Michael Kupferman, Ehab Y. Hanna, Ehab Y. Hanna, Joseph A. Zasadzinski, Joseph A. Zasadzinski, Xiangwei Wu, Xiangwei Wu, Vladimir P. Torchilin, Vladimir P. Torchilin, Dmitri O. Lapotko, Dmitri O. Lapotko, "Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262D (4 March 2014); doi: 10.1117/12.2038277; https://doi.org/10.1117/12.2038277

Back to Top