4 March 2014 Efficient tissue ablation using a laser tunable in the water absorption band at 3 microns with little collateral damage
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Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89262H (2014) https://doi.org/10.1117/12.2049339
Event: SPIE BiOS, 2014, San Francisco, California, United States
Abstract
Lasers can significantly advance medical diagnostics and treatment. At high power, they are typically used as cutting tools during surgery. For lasers that are used as knifes, radiation wavelengths in the far ultraviolet and in the near infrared spectral regions are favored because tissue has high contents of collagen and water. Collagen has an absorption peak around 190 nm, while water is in the near infrared around 3,000 nm. Changing the wavelength across the absorption peak will result in significant differences in laser tissue interactions. Tunable lasers in the infrared that could optimize the laser tissue interaction for ablation and/or coagulation are not available until now besides the Free Electron Laser (FEL). Here we demonstrate efficient tissue ablation using a table-top mid-IR laser tunable between 3,000 to 3,500 nm. A detailed study of the ablation has been conducted in different tissues. Little collateral thermal damage has been found at a distance above 10-20 microns from the ablated surface. Furthermore, little mechanical damage could be seen in conventional histology and by examination of birefringent activity of the samples using a pair of cross polarizing filters.
© (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Alexandra Nierlich, Alexandra Nierlich, Danail Chuchumishev, Danail Chuchumishev, Elizabeth Nagel, Elizabeth Nagel, Kristiana Marinova, Kristiana Marinova, Stanislav Philipov, Stanislav Philipov, Torsten Fiebig, Torsten Fiebig, Ivan Buchvarov, Ivan Buchvarov, Claus-Peter Richter, Claus-Peter Richter, } "Efficient tissue ablation using a laser tunable in the water absorption band at 3 microns with little collateral damage", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262H (4 March 2014); doi: 10.1117/12.2049339; https://doi.org/10.1117/12.2049339
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