4 March 2014 Performance improvement by a broadband super-luminescent diode light source in 1.7-μm spectroscopic spectral-domain optical coherence tomography for lipid distribution imaging in a coronary artery
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Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89262T (2014) https://doi.org/10.1117/12.2038866
Event: SPIE BiOS, 2014, San Francisco, California, United States
Abstract
We develop a 1.7-μm optical coherence tomography (OCT) system using a broadband light source based on superluminescent diodes (SLDs) and investigated the possibility of plaque detection by a spectroscopic OCT (S-OCT) method. The SLD-based light source realizes an output power about 20mW and a 3-dB bandwidth over 120nm for optimization of driving current in each SLD. Regarding performance of the 1.7-μm spectral-domain OCT system with the light source, the system sensitivity is 104dB in maximum at the A-scan rate of 47kHz, which is fifty times as high as that in the previous study with a super-continuum light source. Moreover, we perform visualization of lipid distribution at the A-scan frame of 47kHz by an in-vitro artery model which is made of a piece of porcine coronary artery and a lardfilled nylon tube as a plaque phantom. We confirm that the sensitivity and specificity between artery and plaque area in optimal condition for lipid detection at a specific frame image is over 90% and there are high lipid scores at the inside of plaque phantom in other frame images at the same condition. It indicates the possibility of plaque detection in intravascular OCT.
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M. Tanaka, T. Okuno, H. Obi, I. Hattori, M. Hirano, T. Ueno, S. Tonosaki, K. Murashima, R. Yamaguchi, T. Hasegawa, "Performance improvement by a broadband super-luminescent diode light source in 1.7-μm spectroscopic spectral-domain optical coherence tomography for lipid distribution imaging in a coronary artery", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262T (4 March 2014); doi: 10.1117/12.2038866; https://doi.org/10.1117/12.2038866
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