4 March 2014 Infrared fiber optic probes for evaluation of musculoskeletal tissue pathology
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Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89263Y (2014) https://doi.org/10.1117/12.2047473
Event: SPIE BiOS, 2014, San Francisco, California, United States
Musculoskeletal pathology of the knee commonly occurs with aging and as a result of injury. The incidence of anterior cruciate ligament (ACL) injuries continues to increase annually, and may precede the eventual onset of osteoarthritis (OA), a debilitating and prevalent disease characterized by cartilage degeneration. Early detection of OA remains elusive, with current imaging methods lacking adequate sensitivity to detect early pathologic cartilage changes. We used mid- and near- infrared (IR) spectroscopy through arthroscopic-based fiber-optic devices to assess cartilage damage and differentiate tendon from ligament. Mid-IR spectroscopy is characterized by distinct bands and low penetration depth (< 10 μm) and near-IR spectroscopy is characterized by complex overlapping bands and greater penetration depths (< 1 cm). We have found that combined mid- and near-IR analysis greatly extends the information available through either in the analysis of soft tissues, including cartilage, ligaments and tendons. We discuss here basic science studies and the potential for translation to clinical research with novel arthroscopic probes.
© (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Mugdha Padalkar, Mugdha Padalkar, Cushla McGoverin, Cushla McGoverin, Quam Onigbanjo, Quam Onigbanjo, Richard Spencer, Richard Spencer, Scott Barbash, Scott Barbash, Eric Kropf, Eric Kropf, Nancy Pleshko, Nancy Pleshko, "Infrared fiber optic probes for evaluation of musculoskeletal tissue pathology", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89263Y (4 March 2014); doi: 10.1117/12.2047473; https://doi.org/10.1117/12.2047473

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