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4 March 2014 Photonic hydrogel beads for controlled release of risedronate
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Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 892640 (2014)
Event: SPIE BiOS, 2014, San Francisco, California, United States
pH-sensitive photonic composite hydrogel beads composed of sodium alginate and risedronate sodium (SA/RIS) was prepared crosslinked by Ca2+ owing to the ionic gelation of SA. The structure and surface morphology of the composite hydrogel beads were characterized by SEM. pH-sensitivity of these composite hydrogels beads and the release behaviors of drug from them were investigated. The results showed that the composite hydrogel beads had good pH-sensitivity. The drug loading and encapsulation efficiency were 27.7% and 92% for RIS, respectively. The cumulative release ratios of RIS from the composite hydrogel beads were 2.47% in pH 2.1 solution and 83 % in pH 6.8 solutions within 24 h, respectively. However, the cumulative release ratio of RIS in pH 7.4 solution reached 91% within 7 h. It is proposed that the novel photonic SA/RIS composite hydrogel bead could possess the potential of an increased intestinal absorption and fewer adverse effects of RIS. The pH and salt response of photonic hydrogel bead, as well as the encapsulation of macromolecules, are promising for applications in biomedicine and biotechnology.
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Deepak Kumar Khajuria and D. Roy Mahapatra "Photonic hydrogel beads for controlled release of risedronate", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 892640 (4 March 2014);

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