Photoacoustic and ultrasound dual-modality imaging for inflammatory arthritis

Guan Xu; David Chamberland; Gandikota Girish; Xueding Wang

doi:10.1117/12.2047475

4 March 2014 Photoacoustic and ultrasound dual-modality imaging for inflammatory arthritis

Guan Xu, David Chamberland, Gandikota Girish, Xueding Wang

Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 892643 (2014) https://doi.org/10.1117/12.2047475
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Arthritis is a leading cause of disability, affecting 46 million of the population in the U.S. Rendering new optical contrast in articular tissues at high spatial and temporal resolution, emerging photoacoustic imaging (PAI) combined with more established ultrasound (US) imaging technologies provides unique opportunities for diagnosis and treatment monitoring of inflammatory arthritis. In addition to capturing peripheral bone and soft tissue images, PAI has the capability to quantify hemodynamic properties including regional blood oxygenation and blood volume, both abnormal in synovial tissues affected by arthritis. Therefore, PAI, especially when performed together with US, should be of considerable help for further understanding the pathophysiology of arthritis as well as assisting in therapeutic decisions, including assessing the efficacy of new pharmacological therapies. In this paper, we will review our recent work on the development of PAI for application to the diagnostic imaging and therapeutic monitoring of inflammatory arthritis. We will present the imaging results from a home-built imaging system and another one based on a commercial US. The performance of PAI in evaluating pharmacological therapy on animal model of arthritis will be shown. Moreover, our resent work on PAI and US dual-modality imaging of human peripheral joints in vivo will also be presented.

Citation Download Citation

Guan Xu, David Chamberland, Gandikota Girish, and Xueding Wang "Photoacoustic and ultrasound dual-modality imaging for inflammatory arthritis", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 892643 (4 March 2014); https://doi.org/10.1117/12.2047475

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