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4 March 2014Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter
Tsung-Han Tsai,1 Osman O. Ahsen,1 Hsiang-Chieh Leehttps://orcid.org/0000-0002-2976-6195,1 Kaicheng Liang,1 Michael G. Giacomelli,1 Benjamin M. Potsaid,1,2 Yuankai K. Tao,1 Vijaysekhar Jayaraman,3 Martin F. Kraus,1,4 Joachim Hornegger,4 Marisa Figueiredo,5,6 Qin Huang,5,6 Hiroshi Mashimo,5,6 Alex E. Cable,7 James G. Fujimoto1
1Massachusetts Institute of Technology (United States) 2Thorlabs, Inc. (United States) 3Praevium Research, Inc. (United States) 4Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany) 5VA Boston Healthcare System (United States) 6Harvard Medical School (United States) 7Thorlabs Inc. (United States)
We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical
gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which
provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was
3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was
performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm
with a pixel spacing of 5 μm in the longitudinal direction. Three-dimensional OCT (3D-OCT) imaging was performed in
patients with a cross section of pathologies undergoing standard upper and lower endoscopy at the Veterans Affairs
Boston Healthcare System (VABHS). Patients with Barrett’s esophagus, dysplasia, and inflammatory bowel disease
were imaged. The use of distally actuated imaging catheters allowed OCT imaging with more flexibility such as
volumetric imaging in the terminal ileum and the assessment of the hiatal hernia using retroflex imaging. The high
rotational stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en
face and cross-sectional imaging. The ability to perform 3D OCT imaging in the GI tract with microscopic accuracy
should enable a wide range of studies to investigate the ability of OCT to detect pathology as well as assess treatment
response.
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Tsung-Han Tsai, Osman O. Ahsen, Hsiang-Chieh Lee, Kaicheng Liang, Michael G. Giacomelli, Benjamin M. Potsaid, Yuankai K. Tao, Vijaysekhar Jayaraman, Martin F. Kraus, Joachim Hornegger, Marisa Figueiredo, Qin Huang, Hiroshi Mashimo, Alex E. Cable, James G. Fujimoto, "Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter," Proc. SPIE 8927, Endoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine, 89270T (4 March 2014); https://doi.org/10.1117/12.2040417