Quantitative assessment of brain tissue oxygenation in porcine models of cardiac arrest and cardiopulmonary resuscitation using
hyperspectral near-infrared spectroscopy

Shahin S. Lotfabadi; Vladislav Toronov; Andrew Ramadeen; Xudong Hu; Siwook Kim; Paul Dorian; Gregory M. T. Hare

doi:10.1117/12.2039620

20 March 2014 Quantitative assessment of brain tissue oxygenation in porcine models of cardiac arrest and cardiopulmonary resuscitation using hyperspectral near-infrared spectroscopy

Shahin S. Lotfabadi, Vladislav Toronov, Andrew Ramadeen, Xudong Hu, Siwook Kim, Paul Dorian, Gregory M. T. Hare

Author Affiliations +

Proceedings Volume 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 892815 (2014) https://doi.org/10.1117/12.2039620
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Near-infrared spectroscopy (NIRS) is a non-invasive tool to measure real-time tissue oxygenation in the brain. In an invasive animal experiment we were able to directly compare non-invasive NIRS measurements on the skull with invasive measurements directly on the brain dura matter. We used a broad-band, continuous-wave hyper-spectral approach to measure tissue oxygenation in the brain of pigs under the conditions of cardiac arrest, cardiopulmonary resuscitation (CPR), and defibrillation. An additional purpose of this research was to find a correlation between mortality due to cardiac arrest and inadequacy of the tissue perfusion during attempts at resuscitation. Using this technique we measured the changes in concentrations of oxy-hemoglobin [HbO2] and deoxy-hemoglobin [HHb] to quantify the tissue oxygenation in the brain. We also extracted cytochrome c oxidase changes Δ[Cyt-Ox] under the same conditions to determine increase or decrease in cerebral oxygen delivery. In this paper we proved that applying CPR, [HbO2] concentration and tissue oxygenation in the brain increase while [HHb] concentration decreases which was not possible using other measurement techniques. We also discovered a similar trend in changes of both [Cyt-Ox] concentration and tissue oxygen saturation (StO2). Both invasive and non-invasive measurements showed similar results.

Citation Download Citation

Shahin S. Lotfabadi, Vladislav Toronov, Andrew Ramadeen, Xudong Hu, Siwook Kim, Paul Dorian, and Gregory M. T. Hare "Quantitative assessment of brain tissue oxygenation in porcine models of cardiac arrest and cardiopulmonary resuscitation using hyperspectral near-infrared spectroscopy", Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 892815 (20 March 2014); https://doi.org/10.1117/12.2039620

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