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28 February 2014 Air-puff OCE for assessment of mouse cornea in vivo
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Proceedings Volume 8930, Ophthalmic Technologies XXIV; 893004 (2014)
Event: SPIE BiOS, 2014, San Francisco, California, United States
We characterize the relaxation rates of deformations created by focused air puffs with the use of phasestabilized swept source optical coherence elastography (PhS-SSOCE) in tissue-mimicking gelatin phantoms of various concentrations and mouse corneas of different ages in vivo. The results indicate that gelatin of varying concentrations and corneas from different aged mice have different relaxation rates. In addition, the results show that phantoms with higher concentration gelatin and corneas of older mice have higher relaxation rates, which can be attributed to stiffer material. Because this method is non-contact, noninvasive, and utilizes a minimal force which induces a deformation on the scale of μm, this method can be used to study the biomechanical properties of sensitive tissues, such as the cornea.
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Jiasong Li, Shang Wang, Manmohan Singh, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, and Kirill V. Larin "Air-puff OCE for assessment of mouse cornea in vivo", Proc. SPIE 8930, Ophthalmic Technologies XXIV, 893004 (28 February 2014);

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