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14 March 2014Photodynamic therapy of cervical intraepithelial neoplasia
Photodynamic therapy (PDT) is a technique that has been used for the treatment of tumors, especially in
Gynecology. The photodynamic reaction is based on the production of reactive oxygen species after the
activation of a photosensitizer. Advantages of the PDT in comparison to the surgical resection are:
ambulatory treatment and tissue recovery highly satisfactory, through a non-invasive procedure. The cervical
intraepithelial neoplasia (CIN) grades I and II presents potential indications for PDT. The aim of the proposed
study is to evaluate the safety and efficacy of the PDT for the diagnostics and treatment of CIN I and II. The
equipment and the photosensitizer are produced in Brazil with a representative low cost. It is possible to
visualize the fluorescence of the cervix and to treat the lesions, without side effects. The proposed clinical
protocol shows great potential to become a public health technique.