Photodynamic therapy of cervical intraepithelial neoplasia

Natalia Mayumi Inada; Welington Lombardi M.D.; Marieli Fernanda Martins Leite M.D.; Jose Roberto Trujillo M.D.; Cristina Kurachi D.D.S.; Vanderlei Salvador Bagnato

doi:10.1117/12.2040004

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14 March 2014 Photodynamic therapy of cervical intraepithelial neoplasia

Natalia Mayumi Inada, Welington Lombardi M.D., Marieli Fernanda Martins Leite M.D., Jose Roberto Trujillo M.D., Cristina Kurachi D.D.S., Vanderlei Salvador Bagnato

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Proceedings Volume 8931, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIII; 89310X (2014) https://doi.org/10.1117/12.2040004
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Photodynamic therapy (PDT) is a technique that has been used for the treatment of tumors, especially in Gynecology. The photodynamic reaction is based on the production of reactive oxygen species after the activation of a photosensitizer. Advantages of the PDT in comparison to the surgical resection are: ambulatory treatment and tissue recovery highly satisfactory, through a non-invasive procedure. The cervical intraepithelial neoplasia (CIN) grades I and II presents potential indications for PDT. The aim of the proposed study is to evaluate the safety and efficacy of the PDT for the diagnostics and treatment of CIN I and II. The equipment and the photosensitizer are produced in Brazil with a representative low cost. It is possible to visualize the fluorescence of the cervix and to treat the lesions, without side effects. The proposed clinical protocol shows great potential to become a public health technique.

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Natalia Mayumi Inada, Welington Lombardi M.D., Marieli Fernanda Martins Leite M.D., Jose Roberto Trujillo M.D., Cristina Kurachi D.D.S., and Vanderlei Salvador Bagnato "Photodynamic therapy of cervical intraepithelial neoplasia", Proc. SPIE 8931, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIII, 89310X (14 March 2014); https://doi.org/10.1117/12.2040004

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