4 March 2014 AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction
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Abstract
We demonstrate Adaptive optics - Optical Coherence Tomography (OCT) with modal sensorless Adaptive Optics correction with the use of novel Adaptive Lens (AL) applied for in-vivo imaging of mouse retinas. The AL can generate low order aberrations: defocus, astigmatism, coma and spherical aberration that were used in an adaptive search algorithm. Accelerated processing of the OCT data with a Graphic Processing Unit (GPU) permitted real time extraction of image projection total intensity for arbitrarily selected retinal depth plane to be optimized. Wavefront sensorless control is a viable option for imaging biological structures for which AOOCT cannot establish a reliable wavefront that could be corrected by wavefront corrector. Image quality improvements offered by adaptive lens with sensorless AO-OCT was evaluated on in vitro samples followed by mouse retina data acquired in vivo.
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Stefano Bonora, Yifan Jian, Edward N. Pugh, Marinko V. Sarunic, Robert J. Zawadzki, "AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction", Proc. SPIE 8934, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII, 89340Q (4 March 2014); doi: 10.1117/12.2042018; https://doi.org/10.1117/12.2042018
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