27 February 2014 Mueller polarimetry for the detection of cancers
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Abstract
Polarization measurements allow one to enhance imaging contrast of superficial tissues and obtain new polarization sensitive parameters for better description of the micro- and macro- structural and optical properties of complex tissues. Since the majority of cancers originate in the epithelial layer, probing the morphological and pathological changes in the superficial tissues using an expended parameter set and with improved spatial resolution and contrasts will lead to new clues on the early clinical detection of cancers. In this wok, we carry out polarization imaging on cancerous tissues and look for cancer specific features. Using a scattering model, which approximates the anisotropic biological tissues to a mixture of spherical and cylindrical scatterers imbedded in birefringent ambient media, and a Monte Carlo simulation program, we examine the relationship between the micro-structure of the model and the characteristic polarization features. The studies help to understand the contrast mechanism of polarization sensitive measurements for different cancers and provide the basis for potential clinical applications.
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E. Du, E. Du, Honghui He, Honghui He, Nan Zeng, Nan Zeng, Yihong Guo, Yihong Guo, Minghao Sun, Minghao Sun, Hui Ma, Hui Ma, Shaoxiong Liu, Shaoxiong Liu, Minghua Li, Minghua Li, } "Mueller polarimetry for the detection of cancers", Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89350S (27 February 2014); doi: 10.1117/12.2038853; https://doi.org/10.1117/12.2038853
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