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27 February 2014Development of a fiber based Raman probe compatible with interventional magnetic resonance imaging
Raman spectroscopy has proven to be a powerful tool for discriminating between normal and abnormal tissue types.
Fiber based Raman probes have demonstrated its potential for in vivo disease diagnostics. Combining Raman
spectroscopy with Magnetic Resonance Imaging (MRI) opens up new avenues for MR guided minimally invasive optical
biopsy. Although Raman probes are commercially available, they are not compatible with a MRI environment due to the
metallic components which are used to align the micro-optic components such as filters and lenses at the probe head.
Additionally they are not mechanically compatible with a typical surgical environment as factors such as sterility and
length of the probe are not addressed in those designs. We have developed an MRI compatible fiber Raman probe with a
disposable probe head hence maintaining sterility. The probe head was specially designed to avoid any material that
would cause MR imaging artefacts. The probe head that goes into patient’s body had a diameter <1.5 mm so that it is
compatible with biopsy needles and catheters. The probe has been tested in MR environment and has been proven to be
capable of obtaining Raman signal while the probe is under real-time MR guidance.
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Praveen C. Ashok, Bavishna B. Praveen, Martin Rube, Benjamin Cox, Andreas Melzer, Kishan Dholakia, "Development of a fiber based Raman probe compatible with interventional magnetic resonance imaging," Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89351J (27 February 2014); https://doi.org/10.1117/12.2039805