Diffuse fluorescence tomography based on the radiative transfer equation for small animal imaging

Yihan Wang; Limin Zhang; Huijuan Zhao; Feng Gao; Jiao Li

doi:10.1117/12.2039017

17 February 2014 Diffuse fluorescence tomography based on the radiative transfer equation for small animal imaging

Yihan Wang, Limin Zhang, Huijuan Zhao, Feng Gao, Jiao Li

Proceedings Volume 8937, Multimodal Biomedical Imaging IX; 89370W (2014) https://doi.org/10.1117/12.2039017
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Diffuse florescence tomography (DFT) as a high-sensitivity optical molecular imaging tool, can be applied to in vivo visualize interior cellular and molecular events for small-animal disease model through quantitatively recovering biodistributions of specific molecular probes. In DFT, the radiative transfer equation (RTE) and its approximation, such as the diffuse equation (DE), have been used as the forward models. The RTE-based DFT methodology is more suitable for biological tissue having void-like regions and the near-source area as in the situations of small animal imaging. We present a RTE-based scheme for the steady state DFT, which combines the discrete solid angle method and the finite difference method to obtain numerical solutions of the 2D steady RTE, with the natural boundary condition and collimating light source model. The approach is validated using the forward data from the Monte Carlo simulation for its better performances in the spatial resolution and reconstruction fidelity compared to the DE-based scheme.

Citation Download Citation

Yihan Wang, Limin Zhang, Huijuan Zhao, Feng Gao, and Jiao Li "Diffuse fluorescence tomography based on the radiative transfer equation for small animal imaging", Proc. SPIE 8937, Multimodal Biomedical Imaging IX, 89370W (17 February 2014); https://doi.org/10.1117/12.2039017

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