20 February 2014 Hollow fiber based SERS probe for analysis of biological molecules
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Abstract
A flexible fiber probe for surface-enhanced Raman scattering (SERS) was fabricated by forming gold nanostructures on a ball lens mounted at the distal end of a hollow optical fiber. Two different methods were used to form the gold nanoparticles. In the photochemical deposition, easily fabricated probe indicated good sensitivity, but low reproducibility. On the other hand, in the sputtering method, higher intensity was achieved constantly because an optimal forming condition can be strictly controlled. The measurement of biological molecules using fabricated SERS active probe is also demonstrated.
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M. Nagaoka, T. Katagiri, Y. Matsuura, "Hollow fiber based SERS probe for analysis of biological molecules", Proc. SPIE 8938, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV, 89380Y (20 February 2014); doi: 10.1117/12.2039185; https://doi.org/10.1117/12.2039185
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