20 February 2014 Micro sized implantable ball lens-based fiber optic probe design
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Abstract
A micro sized implantable ball lens-based fiber optic probe design is described for continuous monitoring of brain activity in freely behaving mice. A prototype uses a 500-micron ball lens and a highly flexible 350-micron-diameter fiber bundle, which are enclosed by a 21G stainless steel sheath. Several types and thickness of brain tissue, consisting of fluorescent probes such as GFP, GCaMP3 calcium indicator, are used to evaluate the performance of the imaging probe. Measured working distance is approximately 400-μm, but is long enough to detect neural activities from cortical and cerebellar tissues of mice brain.
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Jaepyeong Cha, Jin U. Kang, "Micro sized implantable ball lens-based fiber optic probe design", Proc. SPIE 8938, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV, 893813 (20 February 2014); doi: 10.1117/12.2038439; https://doi.org/10.1117/12.2038439
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