4 March 2014 Detection of cancerous kidney tissue areas by means of infrared spectroscopy of intercellular fluid
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Abstract
In this work the infrared absorption spectra of intercellular fluid of normal and tumor kidney tissue were recorded and analyzed. The samples were prepared by stamping freshly resected tissue onto a CaF2 substrate. FT-IR spectra obtained from intracellular fluid of tumor tissue exhibit stronger absorption bands in the spectral region from 1000-1200 cm-1 and around 1750 cm-1 than those obtained from normal tissue. It is likely the spectra of extracellular matrix of kidney tumor tissue with large increases in the intensities of these bands represent a higher concentration of fatty acids and glycerol. Amide I and amide II bands are stronger in spectra of normal tissue indicating a higher level of proteins. The results demonstrate that FT-IR spectroscopy of intercellular fluids is a novel approach for a quick diagnosis during surgical resection, which can improve the therapy of kidney tumors.
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V. Urboniene, F. Jankevicius, A. Zelvys, G. Steiner, V. Sablinskas, "Detection of cancerous kidney tissue areas by means of infrared spectroscopy of intercellular fluid ", Proc. SPIE 8939, Biomedical Vibrational Spectroscopy VI: Advances in Research and Industry, 893913 (4 March 2014); doi: 10.1117/12.2038539; https://doi.org/10.1117/12.2038539
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