Brain metastasis detection by resonant Raman optical biopsy method

Yan Zhou; Cheng-hui Liu; Gangge Cheng; Lixin Zhou; Chunyuan Zhang; Yang Pu; Zhongwu Li; Yulong Liu; Qingbo Li; Wei Wang; Robert R. Alfano

doi:10.1117/12.2038731

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17 March 2014 Brain metastasis detection by resonant Raman optical biopsy method

Yan Zhou, Cheng-hui Liu, Gangge Cheng, Lixin Zhou, Chunyuan Zhang, Yang Pu, Zhongwu Li, Yulong Liu, Qingbo Li, Wei Wang, Robert R. Alfano

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Proceedings Volume 8940, Optical Biopsy XII; 89400C (2014) https://doi.org/10.1117/12.2038731
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Resonant Raman (RR) spectroscopy provides an effective way to enhance Raman signal from particular bonds associated with key molecules due to changes on a molecular level. In this study, RR is used for detection of human brain metastases of five kinds of primary organs of lung, breast, kidney, rectal and orbital in ex-vivo. The RR spectra of brain metastases cancerous tissues were measured and compared with those of normal brain tissues and the corresponding primary cancer tissues. The differences of five types of brain metastases tissues in key bio-components of carotene, tryptophan, lactate, alanine and methyl/methylene group were investigated. The SVM-KNN classifier was used to categorize a set of RR spectra data of brain metastasis of lung cancerous tissues from normal brain tissue, yielding diagnostic sensitivity and specificity at 100% and 75%, respectively. The RR spectroscopy may provide new moleculebased optical probe tools for diagnosis and classification of brain metastatic of cancers.

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Yan Zhou, Cheng-hui Liu, Gangge Cheng, Lixin Zhou, Chunyuan Zhang, Yang Pu, Zhongwu Li, Yulong Liu, Qingbo Li, Wei Wang, and Robert R. Alfano "Brain metastasis detection by resonant Raman optical biopsy method", Proc. SPIE 8940, Optical Biopsy XII, 89400C (17 March 2014); https://doi.org/10.1117/12.2038731

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