Parametric study of different contributors to tumor thermal profile

Michal Tepper; Israel Gannot

doi:10.1117/12.2040745

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17 March 2014 Parametric study of different contributors to tumor thermal profile

Michal Tepper, Israel Gannot

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Proceedings Volume 8940, Optical Biopsy XII; 89400P (2014) https://doi.org/10.1117/12.2040745
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Treating cancer is one of the major challenges of modern medicine. There is great interest in assessing tumor development in in vivo animal and human models, as well as in in vitro experiments. Existing methods are either limited by cost and availability or by their low accuracy and reproducibility. Thermography holds the potential of being a noninvasive, low-cost, irradiative and easy-to-use method for tumor monitoring. Tumors can be detected in thermal images due to their relatively higher or lower temperature compared to the temperature of the healthy skin surrounding them. Extensive research is performed to show the validity of thermography as an efficient method for tumor detection and the possibility of extracting tumor properties from thermal images, showing promising results. However, deducing from one type of experiment to others is difficult due to the differences in tumor properties, especially between different types of tumors or different species. There is a need in a research linking different types of tumor experiments. In this research, parametric analysis of possible contributors to tumor thermal profiles was performed. The effect of tumor geometric, physical and thermal properties was studied, both independently and together, in phantom model experiments and computer simulations. Theoretical and experimental results were cross-correlated to validate the models used and increase the accuracy of simulated complex tumor models. The contribution of different parameters in various tumor scenarios was estimated and the implication of these differences on the observed thermal profiles was studied. The correlation between animal and human models is discussed.

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Michal Tepper and Israel Gannot "Parametric study of different contributors to tumor thermal profile", Proc. SPIE 8940, Optical Biopsy XII, 89400P (17 March 2014); https://doi.org/10.1117/12.2040745

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