Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy

Lin Zhang; Yang Pu; Jianpeng Xue; Sebastião Pratavieira; Baogang Xu; Samuel Achilefu; R. R. Alfano

doi:10.1117/12.2038712

17 March 2014 Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy

Lin Zhang, Yang Pu, Jianpeng Xue, Sebastião Pratavieira, Baogang Xu, Samuel Achilefu, R. R. Alfano

Proceedings Volume 8940, Optical Biopsy XII; 894015 (2014) https://doi.org/10.1117/12.2038712
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

This study shows tryptophan as the key native marker in cells to determine the level of aggressive cancer in breast cell lines using native fluorescence spectroscopy. An algorithm based on the ratio of tryptophan fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. The higher the ratio is, the more aggressive the tumor towards metastasis.

Citation Download Citation

Lin Zhang, Yang Pu, Jianpeng Xue, Sebastião Pratavieira, Baogang Xu, Samuel Achilefu, and R. R. Alfano "Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy", Proc. SPIE 8940, Optical Biopsy XII, 894015 (17 March 2014); https://doi.org/10.1117/12.2038712

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