26 February 2014 Objective fitting of hemoglobin dynamics in traumatic bruises based on temperature depth profiling
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Pulsed photothermal radiometry (PPTR) allows noninvasive measurement of laser-induced temperature depth profiles. The obtained profiles provide information on depth distribution of absorbing chromophores, such as melanin and hemoglobin. We apply this technique to objectively characterize mass diffusion and decomposition rate of extravasated hemoglobin during the bruise healing process. In present study, we introduce objective fitting of PPTR data obtained over the course of the bruise healing process. By applying Monte Carlo simulation of laser energy deposition and simulation of the corresponding PPTR signal, quantitative analysis of underlying bruise healing processes is possible. Introduction of objective fitting enables an objective comparison between the simulated and experimental PPTR signals. In this manner, we avoid reconstruction of laser-induced depth profiles and thus inherent loss of information in the process. This approach enables us to determine the value of hemoglobin mass diffusivity, which is controversial in existing literature. Such information will be a valuable addition to existing bruise age determination techniques.
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Luka Vidovič, Luka Vidovič, Matija Milanič, Matija Milanič, Boris Majaron, Boris Majaron, "Objective fitting of hemoglobin dynamics in traumatic bruises based on temperature depth profiling", Proc. SPIE 8941, Optical Interactions with Tissue and Cells XXV; and Terahertz for Biomedical Applications, 894112 (26 February 2014); doi: 10.1117/12.2035792; https://doi.org/10.1117/12.2035792

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