26 February 2014 In vivo label-free monitoring microvascular and lymphatic vessel changes and dynamics during wound healing in mouse ear pinna using optical microangiography
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Abstract
Cutaneous wound healing consists of multiple overlapping phases starting with blood coagulation following incision of blood vessels. In this paper, we briefly review wound healing phases that were observed by utilizing optical microangiography (OMAG) to monitor healing process and dynamics of microcirculation system in a mouse ear pinna wound model. Mouse ear pinna is composed of two layers of skin separated by a layer of cartilage and because its total thickness is around 500 μm, can be utilized as an ideal model for optical imaging techniques. These skin layers are identical to human skin structure except for sweat ducts and glands. Microcirculatory system responds to the wound injury by recruiting collateral vessels to supply blood flow to hypoxic area. Also, lymphatic vessels play an important role in the immune response of the tissue and clearing waste from interstitial fluid.
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Siavash Yousefi, Siavash Yousefi, Ruikang K. Wang, Ruikang K. Wang, } "In vivo label-free monitoring microvascular and lymphatic vessel changes and dynamics during wound healing in mouse ear pinna using optical microangiography", Proc. SPIE 8942, Dynamics and Fluctuations in Biomedical Photonics XI, 89420G (26 February 2014); doi: 10.1117/12.2037985; https://doi.org/10.1117/12.2037985
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