3 March 2014 Integrated intravascular ultrasound and optical-resolution photoacoustic microscopy with a 1-mm-diameter catheter
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Intravascular ultrasound (IVUS) plays a vital role in assessing the severity of atherosclerosis and has greatly enriched our knowledge on atherosclerotic plaques. However, it mainly reveals the structural information of plaques. In contrast, spectroscopic and molecular photoacoustic imaging can potentially improve plaque composition identification, inflammation detection, and ultimately the stratification of plaque vulnerability and risk. In this work, we developed an integrated intravascular ultrasound and optical-resolution photoacoustic microscopy (IVUS-PAM) system with a single catheter as small as 1 mm in diameter, comparable to that of existing clinical IVUS catheters. In addition, by using a GRIN lens to focus the excitation laser pulse, the system provides an optical-diffraction limited photoacoustic lateral resolution as fine as 19.6 micrometers, ~10-fold finer than that of conventional intravascular photoacoustic imaging and existing IVUS technology. The system employs a custom-made miniaturized single-element ultrasonic transducer with a dimension of ~0.5 mm, a centre frequency of ~40 MHz, and a fractional bandwidth of ~60%. The IVUS-PAM can simultaneously acquire co-registered IVUS images with an axial resolution of ~40 micrometers and a lateral resolution of ~200 micrometers. In the future, IVUS-PAM may open up new opportunities for improved high-resolution vulnerable plaque imaging and image-guided stent deployment.
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Xiaosong Bai, Xiaosong Bai, Xiaojing Gong, Xiaojing Gong, Riqiang Lin, Riqiang Lin, William Hau, William Hau, Liang Song, Liang Song, "Integrated intravascular ultrasound and optical-resolution photoacoustic microscopy with a 1-mm-diameter catheter", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894308 (3 March 2014); doi: 10.1117/12.2037017; https://doi.org/10.1117/12.2037017

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