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3 March 2014 Photoacoustic microscopy with an enhanced axial resolution of 5.8 μm
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Abstract
The axial resolution of photoacoustic microscopy (PAM) can be enhanced by reducing the speed of sound within the imaging region of interest. This principle was demonstrated on a previously-reported PAM system, which utilized a 125 MHz ultrasonic transducer for signal detection and the Wiener deconvolution for signal processing. With sound slowed by silicone oil immersion, we have achieved a finest axial resolution of 5.8 μm for PAM, as validated by phantom experiments. The axial resolution was also enhanced in vivo when mouse ears injected with silicone oil were imaged. After injection of silicone oil, the blood vessels were resolved more clearly. When tissue-compatible low-speed liquids become available, this approach may find applications in PAM as well as in other imaging modalities, such as photoacoustic computed tomography and ultrasound imaging.
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Chi Zhang, Yong Zhou, Chiye Li, and Lihong V. Wang "Photoacoustic microscopy with an enhanced axial resolution of 5.8 μm", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894316 (3 March 2014); https://doi.org/10.1117/12.2036832
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