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3 March 2014 Multimodality photoacoustic and Raman imaging of magnetically trapped tumor cells
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Photoacoustic imaging is a novel imaging technology for visualizing optically-absorbing structures in vivo with simultaneous high contrast and high spatial resolution. However, differentiation of photoacoustic signals is non-trivial hence specificity can be poor. We propose multimodality photoacoustic and Raman imaging system using surfaceenhanced Raman scattering nanoparticles, previously demonstrated to have extremely high specificity and multiplexing capabilities. Moreover, we propose to target cancer cells with both magnetic and surface-enhanced Raman scattering nanoparticles, which can further improve our system to be used for magnetic enrichment and detection of circulating tumor cells.
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Wei Shi, Peng Shao, Robert Paproski, Alexander Forbrich, Ronald Moore, and Roger J. Zemp "Multimodality photoacoustic and Raman imaging of magnetically trapped tumor cells", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89431X (3 March 2014);

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