Photoacoustic microscopy with enhanced resolution and imaging depth aided by optical clearing

Yong Zhou; Junjie Yao; Lihong V. Wang

doi:10.1117/12.2036636

3 March 2014 Photoacoustic microscopy with enhanced resolution and imaging depth aided by optical clearing

Yong Zhou, Junjie Yao, Lihong V. Wang

Proceedings Volume 8943, Photons Plus Ultrasound: Imaging and Sensing 2014; 89433A (2014) https://doi.org/10.1117/12.2036636
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (ORPAM) deteriorate sharply with depth due to strong light scattering in tissue. To reduce tissue scattering, we propose to use glycerol as an optical clearing agent in OR-PAM. Our results show that the imaging performance of OR-PAM can be greatly enhanced by optical clearing both in vitro and in vivo.

Citation Download Citation

Yong Zhou, Junjie Yao, and Lihong V. Wang "Photoacoustic microscopy with enhanced resolution and imaging depth aided by optical clearing", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89433A (3 March 2014); https://doi.org/10.1117/12.2036636

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