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3 March 2014 Photoacoustic microscopy for quantitative evaluation of angiogenesis inhibitor
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We present the photoacoustic microscopy (PAM) for evaluation of angiogenesis inhibitors on a chick embryo model. Microvasculature in the chorioallantoic membrane (CAM) of the chick embryos was imaged by PAM, and the optical microscopy (OM) images of the same set of CAMs were also acquired for comparisons, serving for validation of the results from PAM. The angiogenesis inhibitors, Sunitinib, with different concentrations applied to the CAM result in the change in microvascular density, which was quantified by both PAM and OM imaging. Similar change in microvascular density from PAM and OM imaging in response to angiogenesis inhibitor at different doses was observed, demonstrating that PAM has potential to provide objective evaluation of anti-angiogenesis medication. Besides, PAM is advantageous in three-dimensional and functional imaging compared with OM so that the emerging PAM technique may offer unique information on the efficacy of angiogenesis inhibitors and could benefit applications related to antiangiogenesis treatments.
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Sung-Liang Chen, Joseph Burnett, Duxin Sun, Zhixing Xie, and Xueding Wang "Photoacoustic microscopy for quantitative evaluation of angiogenesis inhibitor", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89433S (3 March 2014);

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