3 March 2014 Photoacoustic microscopy of a three-dimensional arbitrary trajectory
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Abstract
We have developed three-dimensional arbitrary trajectory (3-DAT) scanning, which can rapidly image vessels of interest over a large field of view (FOV) and maintain a high signal-to-noise ratio (SNR) along the depth direction. The concept of 3-DAT scanning was demonstrated by imaging a human hair within a FOV of 3.5 × 2.0 mm2. Further, we showed that hemoglobin oxygen saturation (sO2) and blood flow can be measured simultaneously. The frame rate was 67 times faster than a traditional two-dimensional raster scan. We also observed sO2 dynamics in response to a switch between systemic hyperoxia and hypoxia.
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Chenghung Yeh, Brian Soetikno, Song Hu, Konstantin I. Maslov, Lihong V. Wang, "Photoacoustic microscopy of a three-dimensional arbitrary trajectory", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894351 (3 March 2014); doi: 10.1117/12.2037350; https://doi.org/10.1117/12.2037350
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