3 March 2014 Aggregate enhanced trimodal porphyrin shell microbubbles for ultrasound, photoacoustic and fluorescence imaging
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Abstract
Microbubbles (MBs) are currently used as ultrasound (US) contrast agents and as delivery vehicles for site-specific US triggered drug and gene delivery. Multimodal US-based imaging methods have been applied preclinically to assess and validate the effectiveness and fate of MBs as imaging contrast agents and drug delivery vehicles. Here we present the generation of trimodality MBs generated from the dense concentration of porphyrins within a MB shell, enabled by the conjugation of a porphyrin to a phospholipid. These trimodality MBs possess US, photoacoustic and fluorescence properties with potential to expand into other imaging modalities such as MRI and nuclear imaging.
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Elizabeth Huynh, Gang Zheng, "Aggregate enhanced trimodal porphyrin shell microbubbles for ultrasound, photoacoustic and fluorescence imaging", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89435O (3 March 2014); doi: 10.1117/12.2038010; https://doi.org/10.1117/12.2038010
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