27 February 2014 Laser immunotherapy and the tumor-immune system interaction: a mathematical model and analysis
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Proceedings Volume 8944, Biophotonics and Immune Responses IX; 894409 (2014) https://doi.org/10.1117/12.2041814
Event: SPIE BiOS, 2014, San Francisco, California, United States
Abstract
Laser immunotherapy (LIT) is a cancer treatment with promising results in animal models and some `no other option' patients. The therapy elicits an immune response that targets the primary tumor and, perhaps more importantly, otherwise untreatable metastases. We develop and analyze a mathematical model that includes key elements of the host immune response set in motion by LIT. We use Latin Hypercube Sampling (LHS) to EFFICIENTLY sample model parameters from a high-dimensional parameter space and get a broad sense of model dynamics. Depending on a variety of tumor, therapy, and immune parameters, a variety of patient outcomes ranging from tumor clearance to patient death are possible.
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Sean M. Laverty, Bryan A. Dawkins, Wei R. Chen, "Laser immunotherapy and the tumor-immune system interaction: a mathematical model and analysis", Proc. SPIE 8944, Biophotonics and Immune Responses IX, 894409 (27 February 2014); doi: 10.1117/12.2041814; https://doi.org/10.1117/12.2041814
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