A mathematical model of the dynamics of antitumor laser immunotherapy

Bryan A. Dawkins; Sean M. Laverty

doi:10.1117/12.2041810

27 February 2014 A mathematical model of the dynamics of antitumor laser immunotherapy

Bryan A. Dawkins, Sean M. Laverty

Proceedings Volume 8944, Biophotonics and Immune Responses IX; 89440W (2014) https://doi.org/10.1117/12.2041810
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We use a mathematical model to describe and predict the population dynamics of tumor cells, immune cells, and other immune components in a host undergoing laser immunotherapy treatment against metastatic cancer. We incorporate key elements of the treatment into the model: a function describing the laser-induced primary tumor cell death and parameters capturing the role and strength of the primary immunoadjuvant, glycated chitosan. We focus on identifying conditions that ensure a successful treatment. In particular, we study the patient response (i.e., anti-tumor immune dynamics and treatment outcome) in two different but related mathematical models as we vary quantitative features of the immune system (supply, proliferation, death, and interaction rates). We compare immune dynamics of a `baseline' immune model against an `augmented' model (with additional cell types and antibodies) and in both, we find that using strong immunoadjuvants, like glycated chitosan, that enhance dendritic cell activity yields more promising patient outcomes.

Citation Download Citation

Bryan A. Dawkins and Sean M. Laverty "A mathematical model of the dynamics of antitumor laser immunotherapy", Proc. SPIE 8944, Biophotonics and Immune Responses IX, 89440W (27 February 2014); https://doi.org/10.1117/12.2041810

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