Low-power laser irradiation (LPLI) attenuates microglial cytotoxicity through the activation of Src pathway

Sheng Song; Feifan Zhou; Wei R. Chen

doi:10.1117/12.2042415

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27 February 2014 Low-power laser irradiation (LPLI) attenuates microglial cytotoxicity through the activation of Src pathway

Sheng Song, Feifan Zhou, Wei R. Chen

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Proceedings Volume 8944, Biophotonics and Immune Responses IX; 89440Y (2014) https://doi.org/10.1117/12.2042415
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

It has been known for a long time that microglial activation plays an important role in the pathology of neurodegenerative diseases. Once activated, they have macrophage-like capabilities, which can be detrimental by producing proinflammatory and neurotoxic factors including cytokines, reactive oxygen species (ROS) and nitric oxide that directly or indirectly cause neurodegeneration. Therefore, the regulation of microglial-induced neuroinflammation is considered a useful strategy in searching for neuroprotective treatments. In this study, our results showed that low power laser irradiation (LPLI) (20 J/cm²) could suppress microglial-induced neuroinflammation in LPS-activated microglia. We found that LPLI-mediated neuroprotection was achieved by activating tyrosine kinases Src, which led to MyD88 tyrosine phosphorylation, thus impairing MyD88-dependent proinflammatory signaling cascade. Our research may provide a feasible therapeutic approach to control the progression of neurodegenerative diseases.

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Sheng Song, Feifan Zhou, and Wei R. Chen "Low-power laser irradiation (LPLI) attenuates microglial cytotoxicity through the activation of Src pathway", Proc. SPIE 8944, Biophotonics and Immune Responses IX, 89440Y (27 February 2014); https://doi.org/10.1117/12.2042415

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